Biodegradable CSMA/PECA/Graphene Porous Hybrid Scaffold for Cartilage Tissue Engineering

• DOI: 10.1038/srep09879
• Publication Date: 2015-05-11T12:58:01Z
• Authors: JinFeng Liao; Ying Qu; BingYang Chu; XiaoNing Zhang; ZhiYong Qian
• Keywords: Tissue Engineering; Tissue Scaffolds; Chondroitin Sulfates; 3T3 Cells; 02 engineering and technology; Article; Rats; Mice; Cartilage; Absorbable Implants; Materials Testing; Animals; Graphite; Cyanoacrylates; Rabbits; Rats, Wistar; 0210 nano-technology; Porosity

Abstract Owing to the limited repair capacity of articular cartilage, it is essential develop tissue-engineered cartilage for patients suffering from joint disease and trauma. Herein, we prepared a novel hybrid scaffold composed methacrylated chondroitin sulfate (CSMA), poly(ethylene glycol) methyl ether-ε-caprolactone-acryloyl chloride (MPEG-PCL-AC, PECA was used as abbreviation MPEG-PCL-AC) graphene oxide (GO) evaluated its potential application in tissue engineering. To mimic natural extracellular matrix (ECM) had an adequate pore size, porosity, swelling ability, compression modulus conductivity. Cartilage cells contacted with remained viable showed growth potential. Furthermore, CSMA/PECA/GO biocompatible favorable degradation rate. In rabbit, Micro-CT histology observation group cellular supplementation better chondrocyte morphology, integration, continuous subchondral bone much thicker newly formed compared control group. Our results show that porous can be applied engineering may have great other types applications.