Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

• DOI: 10.1038/srep10949
• Publication Date: 2015-06-16T10:53:53Z
• Authors: Mohamed Abu-Farha; Jehad Abubaker; Irina Al-Khairi; Preethi Cherian; Fiona Noronha; Frank B. Hu; Kazem Behbehani; Naser Elkum
• Keywords: Adult; Blood Glucose; Glycated Hemoglobin; Male; 0301 basic medicine; 571; Peptide Hormones; Age Factors; Fibrinogen; Cholesterol, LDL; Middle Aged; Lipid Metabolism; Article; Body Mass Index; 03 medical and health sciences; Angiopoietin-like Proteins; Diabetes Mellitus, Type 2; Angiopoietin-Like Protein 8; Case-Control Studies; Humans; Insulin; Female; Insulin Resistance; Aged

Abstract Betatrophin/ANGPTL8 is a newly identified hormone produced in liver and adipose tissue that has been shown to be induced as result of insulin resistance regulates lipid metabolism. Little known about betatrophin level humans its association with T2D metabolic risk factors. Plasma was measured by ELISA 1603 subjects: 1047 non-diabetic 556 subjects associations factors both were also studied. Our data show significant difference levels between (731.3 (59.5–10625.0) pg/ml) (1710.5 (197.4–12361.1) p < 0.001. Betatrophin positively correlated age, BMI, waist/hip ratio, FBG, HbA1C, HOMA-IR TG the subjects. However, no observed HbA1C or TC LDL showed negative Multivariate analysis highest tertile had higher odds having (odd ratio [OR] = 6.15, 95% confidence interval [CI] (3.15 – 12.01). strong positive FBG correlations diminished