Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster

• DOI: 10.1038/srep12383
• Publication Date: 2015-07-22T09:54:33Z
• Authors: Leire Herboso; Marisa M. Oliveira; Ana Talamillo; Coralia Pérez; Monika González; David Martín; James D. Sutherland; Alexander W. Shin...; Christen K. Mirth; Rosa Barrio
• Keywords: Ecdysone receptor

Abstract Animals have a determined species-specific body size that results from the combined action of hormones and signaling pathways regulating growth rate duration. In Drosophila , steroid hormone ecdysone controls developmental transitions, thereby duration period. Here we show promotes imaginal discs in mid-third instar larvae, since larvae with reduced or no synthesis are smaller than wild type due to fewer cells. We insulin-like peptides produced secreted normally upstream components insulin/insulin-like activated their discs. Instead, appears regulate via Thor/4E-BP negative regulator downstream factor/Tor pathways. Discs elevated levels Thor while mutations partially rescue growth. The regulation organ by is evolutionarily conserved hemimetabolous insects, as shown our obtained using Blattella germanica . summary, data provide new insights into relationship between insulin/insulin-like/Tor control