Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form

• DOI: 10.1038/srep15685
• Publication Date: 2015-10-23T10:14:18Z
• Authors: Hyo Jung Seo; Sang Hwan Nam; Hyung-Jun Im; Ji-yong Park; Ji Youn Lee; Byeongjun Yoo; Yun-Sang Lee; Jae Min Jeong; Taeghwan Hyeon; Ji Who Kim; Jae Sung Lee; In-Jin Jang; Joo-Youn Cho; Do Won Hwang; Yung Doug Suh; Dong Soo Lee
• Keywords: Biodistribution; Ex vivo; Mononuclear phagocyte system

In the field of nanomedicine, long term accumulation nanoparticles (NPs) in mononuclear phagocyte system (MPS) such as liver is major hurdle clinical translation. On other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it critical to develop that show favorable property. Herein, we demonstrated micelle encapsulated (64)Cu-labeled upconverting (micelle (64)Cu-NOTA-UCNPs) showed substantial by vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex biodistribution study reinforced results showing clearance 84% initial hepatic uptake 72 hours. Hepatobiliary UCNPs was verified transmission electron microscopy (TEM) examination. Micelle (64)Cu-NOTA-UCNPs an optimal bimodal agent owing quantifiability (64)Cu, ability vivo/ex ULI good