Genetic variations in STAT4,C2,HLA-DRB1 and HLA-DQ associated with risk of hepatitis B virus-related liver cirrhosis

• DOI: 10.1038/srep16278
• Publication Date: 2015-11-05T10:36:01Z
• Authors: De-Ke Jiang; Xiao-Pin Ma; Xiaopan Wu; Lijun Peng; Jianhua Yin; Yunjie Dan; Hui-Xing Huang; Dong-Lin Ding; Lu-Yao Zhang; Zhuqing Shi; Pengyin Zhang; Hongjie Yu; Jielin Sun; S. Lilly Zheng; Guohong Deng; Jianfeng Xu; Ying Liu; Jinsheng Guo; Guangwen Cao; Long Yu
• Keywords: Genome-wide Association Study; SNP; Genetic Association; HLA-DQ

Abstract Recent genome-wide associated studies (GWASs) have revealed several common loci with the risk of hepatitis B virus (HBV)- or C (HCV)-related hepatocellular carcinoma (HCC). We selected 15 single nucleotide polymorphisms (SNPs) identified through GWASs on HBV- HCV-related HCC and genotyped them in two independent Chinese cohorts chronic HBV carriers, including 712 LC cases 2601 controls. The association each SNP HBV-related was assessed by meta-analysis cohorts. Of 12 SNPs reported GWASs, five (rs7574865 STAT4 , rs9267673 near C2 rs2647073 rs3997872 HLA-DRB1 rs9275319 HLA-DQ ), were found to be significantly (rs7574865: P = 1.79 × 10 −2 OR 1.17, 95% CI 1.03–1.34; rs9267673: 4.91 −4 1.37, 1.15–1.63; rs2647073: 3.53 −5 1.63, 1.29–2.06; rs3997872: 4.22 1.86, 1.32–2.62; rs9275319: 1.30 1.32, 1.06–1.64). However, among three previous none showed significant LC. Our results suggested that genetic variants hepatocarcinogenesis may already play an important role progression from CHB