SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α

• DOI: 10.1038/srep16396
• Publication Date: 2015-11-09T10:35:09Z
• Authors: Qilin Ao; Wenjing Su; Shuang Guo; Lei Cai; Lei Huang
• Keywords: Ovarian Neoplasms; 0301 basic medicine; Sumoylation; Antineoplastic Agents; Hypoxia-Inducible Factor 1, alpha Subunit; Article; Cell Hypoxia; 3. Good health; Gene Expression Regulation, Neoplastic; Cysteine Endopeptidases; 03 medical and health sciences; Drug Resistance, Neoplasm; Cell Line, Tumor; Endopeptidases; Humans; Female; Cisplatin

AbstractHypoxia-inducible factor 1 alpha (HIF-1α) is closely related to chemoresistance of ovarian cancers. Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial. In this study, we identified that SENP1 positively regulated the expression of HIF-1α by deSUMOylation and weakened the sensitivity of hypoxic ovarian cancer cells to cisplatin. These results indicate that SENP1 is a positive regulator of HIF-1α and plays a negative role in ovarian cancer chemotherapy.