Differential effect of DJ-1/PARK7 on development of natural and induced regulatory T cells

• DOI: 10.1038/srep17723
• Publication Date: 2015-12-04T10:23:23Z
• Authors: Yogesh Singh; Hong Chen; Yuetao Zhou; Michael Föller; Tak W. Mak; Madhuri S. Salker; Florian Lang
• Keywords: CD4-Positive T-Lymphocytes; Mice, Knockout; Oncogene Proteins; 0303 health sciences; TOR Serine-Threonine Kinases; Protein Deglycase DJ-1; Intracellular Signaling Peptides and Proteins; PTEN Phosphohydrolase; Cell Differentiation; Forkhead Transcription Factors; T-Lymphocytes, Regulatory; Article; 3. Good health; Mice; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Immune Tolerance; Animals; Proto-Oncogene Proteins c-akt; Signal Transduction

Regulatory T cells (Tregs) are essential for maintaining an effective immune tolerance and a homeostatic balance of various other cells. To manipulate the response during infections autoimmune disorders, it is to know which genes or key molecules involved in development Tregs. Transcription factor Foxp3 required Tregs governs most suppressive functions these Inhibited PI3K/AKT/mTOR signalling critical stability. Previous studies have suggested that DJ-1 PARK7 protein positive regulator pathway by negatively regulating activity PTEN. Thus, we hypothesised lack could promote As result, loss decreased total CD4(+) cell numbers but increased fraction thymic peripheral nTregs. In contrast, generation was not augmented following differentiation DJ-1-deficient naïve DJ-1-deficient-iTregs were imperfect replication, proliferation more prone death. Furthermore, deficient iTregs less sensitive pSmad2 pStat5 had activated AKT/mTOR signalling. These observations reveal unexpected differential role nTregs iTregs.