Hepatic steatosis depresses alpha-1-antitrypsin levels in human and rat acute pancreatitis

• DOI: 10.1038/srep17833
• Publication Date: 2015-12-04T10:13:35Z
• Authors: Qian Wang; Jianjun Du; Pengfei Yu; Bin Bai; Zhanwei Zhao; Shiqi Wang; Junjie Zhu; Quanxin Feng; Yun Gao; Qingchuan Zhao; Chaoxu Liu
• Keywords: Steatosis; Alpha (finance)

Abstract Hepatic steatosis (HS) can exacerbate acute pancreatitis (AP). This study aimed to investigate the relation between α1-antitrypsin (AAT) and when patients have HS. Using proteomic profiling, we identified 18 differently expressed proteins pots in serum of rats with or without HS after surgical establishment AP. AAT was found be one significantly down-regulated proteins. levels were lower hepatic (HSAP) than non-HSAP (NHSAP) (P < 0.001). To explore clinical significance these observations, measured 240 HSAP, NHSAP, fatty liver disease (FLD), no disease. Compared healthy controls, NHSAP higher 0.01), while HSAP 0.01). Further studies showed that physiology chronic health evaluation (APACHE-II) scores negatively correlated (r = −0.85, P In conclusion, low are severity may represent a potential target for therapies aiming improve pancreatitis.