Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10

• DOI: 10.1038/srep20084
• Publication Date: 2016-02-02T10:40:45Z
• Authors: Zhigang Mao; Jeffrey H. Wu; Tingting Dong; Mei X. Wu
• Keywords: Hydroxyproline; Coenzyme Q10

Abstract Diabetes, a highly prevalent disease that affects 9.3% of Americans, often leads to severe complications and slow wound healing. Preclinical studies have suggested low level light therapy (LLLT) can accelerate healing in diabetic subjects, but significant improvements must be made overcome the absence persuasive evidence for its clinical use. We demonstrate here LLLT combined with topical Coenzyme Q10 (CoQ10) heal wounds mice significantly faster than alone, CoQ10 or controls. followed by enhanced 68~103% first week more 24% second compared untreated All were fully healed two weeks following dual treatment, contrast only 50% fewer being single sham treatment. The accelerated was corroborated at least higher hydroxyproline levels tripling cell proliferation rates treated over beneficial effects on probably attributed additive enhancement ATP production combination is safe convenient merits further study.