Changing pattern in the basal ganglia: motor switching under reduced dopaminergic drive

• DOI: 10.1038/srep23327
• Publication Date: 2016-03-23T09:56:46Z
• Authors: Vincenzo G. Fiore; Francesco Rigoli; Max-Philipp Stenner; Tino Zaehle; Frank Hirth; Hans-Jochen Heinze; Raymond J. Dolan
• Keywords: Subthalamic Nucleus; Motor System; Motor symptoms; Motor Control; Action selection

Abstract Action selection in the basal ganglia is often described within framework of a standard model, associating low dopaminergic drive with motor suppression. Whilst powerful, this model does not explain several clinical and experimental data, including varying therapeutic efficacy across movement disorders. We tested predictions patients Parkinson’s disease, on off subthalamic deep brain stimulation (DBS), focussing adaptive sensory-motor responses to changing environment maintenance an action until it no longer suitable. Surprisingly, we observed prolonged perseverance under on-stimulation, high inter-individual variability terms selections performed when comparing two conditions. To account for these revised exploring its space parameters associated functions found that, depending effective connectivity between external internal parts globus pallidus saliency sensory input, can result increased, dysfunctional, switching, besides This new provides insight into biophysical mechanisms underlying DBS, allowing description alteration signal-to-baseline ratio indirect pathway, which better known electrophysiological data comparison model.