A non-human primate model of radiation-induced cachexia

• DOI: 10.1038/srep23612
• Publication Date: 2016-03-31T09:06:12Z
• Authors: Wanchang Cui; Alexander W. Bennett; Pei Zhang; Kory R. Barrow; Sean R. Kearney; Kim G. Hankey; Cheryl Taylor-Howell; Allison M. Gibbs; Cassandra P. Smith; Thomas J. MacVittie
• Keywords: Male; Cachexia; SKP Cullin F-Box Protein Ligases; Time Factors; Activin Receptors, Type II; Dose-Response Relationship, Radiation; Myostatin; Macaca mulatta; Article; 3. Good health; Disease Models, Animal; Hemoglobins; Muscular Atrophy; 03 medical and health sciences; 0302 clinical medicine; Gene Expression Regulation; Gamma Rays; Weight Loss; Animals; Humans; Muscle, Skeletal; Serum Albumin; Retrospective Studies

Cachexia, or muscle wasting, is a serious health threat to victims of radiological accidents patients receiving radiotherapy. Here, we propose non-human primate (NHP) radiation-induced cachexia model based on clinical and molecular pathology findings. NHP exposed potentially lethal partial-body irradiation developed symptoms such as body weight loss in time- dose-dependent manner. Severe high 20-25% was observed which refractory nutritional intervention. Radiographic imaging indicated that cachectic lost much 50% skeletal muscle. Histological analysis tissues showed abnormalities presence central nuclei, inflammation, fatty replacement muscle, fiber degeneration. Biochemical parameters hemoglobin albumin levels decreased after radiation exposure. Levels FBXO32 (Atrogin-1), ActRIIB myostatin were significantly changed the irradiated compared non-irradiated NHP. Our data suggest have been dose manifest cachexia-like This provides unique opportunity study mechanism will aid efficacy studies mitigators this disease.