Caffeine intake antagonizes salt sensitive hypertension through improvement of renal sodium handling

• DOI: 10.1038/srep25746
• Publication Date: 2016-05-12T10:32:05Z
• Authors: Hao Yu; Tao Yang; Peng Gao; Xing Wei; Hexuan Zhang; Shiqiang Xiong; Zongshi Lu; Li Li; Xiao Wei; Jing Chen; Yu Zhao; William J. Arends...; Qianhui Shang; Daoyan Liu; Zhiming Zhu
• Keywords: Epithelial sodium channel

Abstract High salt intake is a major risk factor for hypertension. Although acute caffeine produces moderate diuresis and natriuresis, increases the blood pressure (BP) through activating sympathetic activity. However, long-term effects of on urinary sodium excretion are rarely investigated. Here, we investigated whether chronic administration antagonizes sensitive hypertension by promoting excretion. Dahl salt-sensitive (Dahl-S) rats were fed with high diet or without 0.1% in drinking water 15 days. The BP, heart rate locomotor activity was analyzed determined. renal epithelial Na + channel (ENaC) expression function measured vivo vitro experiments. Chronic consumption attenuates induced affecting nerve Dahl-S rats. α-ENaC ENaC decreased after administration. Caffeine increased phosphorylation AMPK decrease cortical collecting duct cells. Inhibiting abolished effect α-ENaC. prevented development excretion, which associated activation inhibition tubular ENaC.