Changes in profile of lipids and adipokines in patients with newly diagnosed hypothyroidism and hyperthyroidism

• DOI: 10.1038/srep26174
• Publication Date: 2016-05-20T20:23:42Z
• Authors: Yanyan Chen; Xiafang Wu; Ruirui Wu; Xiance Sun; Boyi Yang; Yi Wang; Yuanyuan Xu
• Keywords: Resistin; Lipid Profile; Thyroid-stimulating hormone

Abstract Changes in profile of lipids and adipokines have been reported patients with thyroid dysfunction. But the evidence is controversial. The present study aimed to explore relationships between function adipokines. A cross-sectional was conducted 197 newly diagnosed hypothyroid patients, 230 hyperthyroid 355 control subjects. Hypothyroid presented significantly higher serum levels total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDLC), fasting insulin, resistin leptin than ( p < 0.05). Hyperthyroid lower high-density LDLC leptin, as well resistin, adiponectin homeostasis model insulin resistance index (HOMA-IR) Nonlinear regression multivariable linear models all showed significant associations or free thyroxine association thyroid-stimulating hormone 0.001). Furthermore, correlation HOMA-IR observed Thus, dysfunction affects Resistin may serve a link resistance.