Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays

• DOI: 10.1038/srep27822
• Publication Date: 2016-06-10T09:29:17Z
• Authors: Caiye Zhu; Hongying Fan; Zehu Yuan; Shijin Hu; Xiaomeng Ma; Junli Xuan; Hongwei Wang; Li Zhang; Caihong Wei; Qin Zhang; Fuping Zhao; Lixin Du
• Keywords: SNP; Genome-wide Association Study; SNP array

Abstract Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fat-rumped, and thin-tailed sheep, of which the typical breeds are large-tailed Han Altay Tibetan respectively. To unravel genetic mechanisms underlying phenotypic differences among with tails different types, we used ovine high-density 600K SNP arrays to detect genome-wide copy number variation (CNV). In 371, 301, 66 CNV regions (CNVRs) lengths 71.35 Mb, 51.65 10.56 respectively, were identified autosomal chromosomes. Ten CNVRs randomly chosen for confirmation, eight successfully validated. The detected harboured 3130 genes, including genes associated fat deposition, such as PPARA, RXRA, KLF11, ADD1, FASN, PPP1CA, PDGFA , PEX6 . Moreover, multilevel bioinformatics analyses candidate significantly enriched involvement in GTPase regulator, peptide receptor activities. This is first high-resolution map tails. Our results provide valuable information that will support investigations genomic structural traits interest sheep.