Ecophysiological consequences of alcoholism on human gut microbiota: implications for ethanol-related pathogenesis of colon cancer

• DOI: 10.1038/srep27923
• Publication Date: 2016-06-13T13:54:06Z
• Authors: Atsuki Tsuruya; Akika Kuwahara; Yuta Saito; Haruhiko Yamaguchi; Takahisa Tsubo; Shogo Suga; Makoto Inai; Yuichi Aoki; Seiji Takahashi; Eri Tsutsumi; Yoshihide Suwa; Hidetoshi Morita; Kenji Kinoshita; Yukari Totsuka; Wataru Suda; Kenshiro Oshima; Masahira Hattori; Takeshi Mizukami; Akira Yokoyama; Takefumi Shimoyama; Toru Nakayama
• Keywords: Obligate; Pathogenesis; Ruminococcus; Obligate anaerobe

Abstract Chronic consumption of excess ethanol increases the risk colorectal cancer. The pathogenesis ethanol-related cancer (ER-CRC) is thought to be partly mediated by gut microbes. Specifically, bacteria in colon and rectum convert acetaldehyde (AcH), which carcinogenic. However, effects chronic on human microbiome are poorly understood role microbes proposed AcH-mediated ER-CRC remains elaborated. Here we analyse compare microbiota structures non-alcoholics alcoholics. microbiotas alcoholics were diminished dominant obligate anaerobes ( e.g ., Bacteroides Ruminococcus ) enriched Streptococcus other minor species. This alteration might exacerbated habitual smoking. These observations could at least explained susceptibility reactive oxygen species, increased exposure mucosa ethanol. AcH productivity from was much lower faeces alcoholic patients than non-alcoholic subjects. faecal phenotype rationalised based their ability accumulate