Gene Expression Profiling of Breast Cancer Brain Metastasis

• DOI: 10.1038/srep28623
• Publication Date: 2016-06-24T09:13:45Z
• Authors: Ji Yun Lee; Kyunghee Park; Eunjin Lee; TaeJin Ahn; Hae Hyun Jung; Sung Hee Lim; Mineui Hong; In-Gu Do; Eun Yoon Cho; Duk-Hwan Kim; Ji-Yeon Kim; Jin Seok Ahn; Young-Hyuck Im; Yeon Hee Park
• Keywords: Primary tumor

Abstract The biology of breast cancer brain metastasis (BCBM) is poorly understood. We aimed to explore genes that are implicated in the process primary (BC). NanoString nCounter Analysis covering 252 target was used for comparison gene expression levels between 20 BCs relapsed and 41 BCBM samples. PAM50-based intrinsic subtypes such as HER2-enriched basal-like were clearly over-represented BCBM. A panel 22 found be significantly differentially expressed BC Five these genes, CXCL12 , MMP2 MMP11 VCAM1 MME which have previously been associated with tumor progression, angiogenesis, metastasis, discriminated Notably, five upregulated compared Conversely, SOX2 OLIG2 These may participate metastatic colonization but not development. Among patient-matched paired samples ( n = 17), a PAM50 molecular subtype conversion observed eight cases (47.1%), trend toward unfavorable patients distinct expression. Our findings, although conclusive, reveal might mediate process.