Bisphenol A Exposure May Induce Hepatic Lipid Accumulation via Reprogramming the DNA Methylation Patterns of Genes Involved in Lipid Metabolism

• DOI: 10.1038/srep31331
• Publication Date: 2016-08-09T09:46:36Z
• Authors: Zhang-Hong Ke; Jie-Xue Pan; Lu-Yang Jin; Hai-Yan Xu; Tian-Tian Yu; Kamran Ullah; Tanzil Ur Rahman; Jun Ren; Yi Cheng; Xin-Yan Dong; Jian-Zhong Sheng; He-Feng Huang
• Keywords: Reprogramming

Abstract Accumulating evidence suggests a role of bisphenol A (BPA) in metabolic disorders. However, the underlying mechanism is still unclear. Using mouse BPA exposure model, we investigated effects long-term on lipid metabolism and mechanisms. The male mice exposed to (0.5 μg /kg/day, human relevant dose) for 10 months exhibited significant hepatic accumulation triglycerides cholesterol. liver cells from BPA-exposed showed significantly increased expression levels genes related synthesis. These decreased DNA methylation Srebf1 Srebf2, Srebf2 that may upregulate methyltransferases were liver. Hepa1-6 cell line treated with involved methyltransferase knockdown led hypo-methylation Our results suggest could induce accumulation, which be due epigenetic reprogramming metabolism, such as alterations patterns.