Imaging biomarkers for steatohepatitis and fibrosis detection in non-alcoholic fatty liver disease

• DOI: 10.1038/srep31421
• Publication Date: 2016-08-12T09:16:58Z
• Authors: Rocío Gallego-Durán; Pablo Cerro-Salido; Emilio Gomez-Gonz...; María Jesús Pareja; Javier Ampuero; María Carmen Rico; Rafael Aznar; Eduardo Vilar-Gomez; Elisabetta Bugianesi; Javier Crespo; Francisco José Go...; Reyes Aparcero; Inmaculada Moreno; Susana Soto; María Teresa Aria...; Javier Abad; Isidora Ranchal; Raúl Jesús Andrade; Jose Luis Calleja; Miguel Pastrana; Oreste Lo Iacono; Manuel Romero-Gómez
• Keywords: Steatohepatitis

Abstract There is a need, in NAFLD management, to develop non-invasive methods detect steatohepatitis (NASH) and predict advanced fibrosis stages. We evaluated tool based on optical analysis of liver magnetic resonance images (MRI) as biomarkers for NASH detection by investigating patients with biopsy-proven who underwent (MR) protocols using 1.5T General Electric (GE) or Philips devices. Two imaging (NASHMRI FibroMRI) were developed, standardised validated area under the receiver operating characteristic curve (AUROC) analysis. The results indicated NASHMRI diagnostic accuracy was 0.83 (95% CI: 0.73–0.93) FibroMRI significant determination 0.85 0.77–0.94). These findings independent MR system used. conclude that MRI has high potential define (NASHMRI) prediction (FibroMRI) patients.