Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson’s Disease

• DOI: 10.1038/srep33738
• Publication Date: 2016-09-22T08:58:28Z
• Authors: Natasa Kustrimovic; Emanuela Rasini; Massimiliano Legnaro; Raffaella Bombelli; Iva Aleksic; Fabio Blandini; Cristoforo Comi; Marco Mauri; Brigida Minafra; Giulio Riboldazzi; Vanesa Sanchez-Gu...; Franca Marino; Marco Cosentino
• Keywords: Pars compacta

Abstract Parkinson’s disease (PD) is characterized by loss of dopaminergic neurons in substantia nigra pars compacta, α-synuclein (α-syn)-rich intraneuronal inclusions (Lewy bodies), and microglial activation. Emerging evidence suggests that CD4+ T lymphocytes contribute to neuroinflammation PD. Since the mainstay PD treatment substitution therapy dopamine an established transmitter connecting nervous immune systems, we examined naive memory patients healthy subjects (HS), with specific regard receptor (DR) expression. In addition, vitro effects α-syn were assessed on cells. Results showed extensive association between DR expression motor dysfunction, as UPDRS Part III score. total cells D 1 -like decrease, while 2 increase increasing , increased cells, possibly a different extent HS, affected cell subset-specific patterns. The present results support involvement peripheral adaptive immunity PD, may develop novel immunotherapies for well better use current antiparkinson drugs.