Prognostic significance of miR-1268a expression and its beneficial effects for post-operative adjuvant transarterial chemoembolization in hepatocellular carcinoma

• DOI: 10.1038/srep36104
• Publication Date: 2016-10-31T10:50:44Z
• Authors: Yun-Long Lu; Jin-Guang Yao; Xiao-Ying Huang; Chao Wang; Xue-Min Wu; Qiang Xia; Xi-Dai Long
• Keywords: Adjuvant Therapy

Our recent investigation has shown that the variables of microRNA-1268a may involve in hepatocellular carcinoma (HCC) tumorigenesis. Here, we attempted to identify prognostic significance expression tumor tissues by a retrospective analysis 411 patients with HCC, and analyze its effects on post-operative adjuvant transarterial chemoembolization (TACE) improving HCC prognosis. All cases received resection or plus TACE as an initial treatment. Logistical regression exhibited was significantly correlated stage, grade, size, microvessel density. Cox showed independent factor for treatment had no prognosis high expression. More intriguingly, improved low Functionally, overexpression inhibited while inhibitor enhanced doxorubicin-induced death cancer cells. These results suggest be patients, decreasing beneficial HCC.