Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents

• DOI: 10.1038/srep36202
• Publication Date: 2016-10-26T09:25:50Z
• Authors: Christine Langlois; Arkan Abadi; Jesus Peralta-Romero; Akram Alyass; Fernando Suarez; Jaime Gomez-Zamudio; Ana I. Burguete-G...; Fereshteh T. Yazdi; Miguel Cruz; David Meyre
• Keywords: Genome-wide Association Study; Genetic Association

Abstract Genome wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) that are associated with fasting plasma glucose (FPG) in adult European populations. The contribution of these SNPs to FPG non-Europeans and children is unclear. We studied the 15 GWAS a genotype score (GS) 7 metabolic traits 1,421 Mexican adolescents from Mexico City. Genotyping was performed using TaqMan Open Array. used multivariate linear regression models adjusted for age, sex, body mass index standard deviation score, recruitment center. significant associations between 3 ( G6PC2 (rs560887), GCKR (rs1260326), MTNR1B (rs10830963)), GS level. risk alleles 11 out (73.3%) displayed or non-significant beta values directionally consistent those reported GWAS. allele frequencies differed significantly compared adults 1000G Project, but no enrichment observed population. Our data support partial transferability signals admixed