HMGA1P7-pseudogene regulates H19 and Igf2 expression by a competitive endogenous RNA mechanism

• DOI: 10.1038/srep37622
• Publication Date: 2016-11-22T10:10:52Z
• Authors: Marco De Martino; Floriana Forzati; Marianna Marfella; Simona Pellecchia; Claudio Arra; Luigi Terracciano; Alfredo Fusco; Francesco Esposito
• Keywords: Pseudogene; Competing Endogenous RNA; Piwi-interacting RNA

Abstract Recent studies have revealed that pseudogene transcripts can function as competing endogenous RNAs, and thereby also contribute to cancer when dysregulated. We recently identified two pseudogenes, HMGA1P6 HMGA1P7 for the HMGA1 gene whose overexpression has a critical role in progression. These pseudogenes work competitive RNA decoys other related genes suggesting their carcinogenesis. Looking new ceRNAs, we performed sequencing technology on mouse embryonic fibroblasts deriving from transgenic mice overexpressing HMGA1P7. Here, report mRNA sustains H19 Igf2 by acting miRNA decoy. Lastly, expression of was significantly correlated with IGF2 levels human breast deregulation this neoplasia.