A pathway-centric view of spatial proximity in the 3D nucleome across cell lines

• DOI: 10.1038/srep39279
• Publication Date: 2016-12-15T13:25:07Z
• Authors: Hiren Karathia; Carl Kingsford; Michelle Girvan; Sridhar Hannenhalli
• Keywords: Housekeeping gene; Spatial contextual awareness

Abstract In various contexts, spatially proximal genes have been shown to be functionally related. However, the extent which spatial proximity of in a pathway contributes pathway’s context-specific activity is not known. Leveraging Hi-C data six human cell-lines, we show that highly correlated with expression and function. Furthermore, correlates interactions their protein products, specific are one another tend occupy higher levels regulatory hierarchy. addition intra-pathway proximity, related pathways housekeeping-genes several other suggesting coordinating role. Substantially extending previous works, our study reveals pathway-centric organization 3D-nucleome, whereby, interacting driver spatial-proximity manner.