Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

• DOI: 10.1038/srep40373
• Publication Date: 2017-01-20T12:29:12Z
• Authors: Sarah Bettini; Elisa Boutet-Robinet; Christel Cartier; Christine Coméra; Eric Gaultier; Jacques Dupuy; Nathalie Naud; Sylviane Taché; Patrick Grysan; Solenn Reguer; Nathalie Thieriet; Matthieu Réfrégiers; Dominique Thiaudière; Jean-Pierre Cravedi; Marie Carrière; Jean-Nicolas Audinot; Fabrice H. Pierre; Laurence Guzylack...; Eric Houdeau
• Keywords: Aberrant crypt foci; Homeostasis

Abstract Food-grade titanium dioxide (TiO 2 ) containing a nanoscale particle fraction -NPs) is approved as white pigment (E171 in Europe) common foodstuffs, including confectionary. There are growing concerns that daily oral TiO -NP intake associated with an increased risk of chronic intestinal inflammation and carcinogenesis. In rats orally exposed for one week to E171 at human relevant levels, was detected the immune cells Peyer’s patches (PP) observed model NM-105. Dendritic cell frequency PP regardless treatment, while regulatory T involved dampening inflammatory responses decreased only, effect still after 100 days treatment. all -treated rats, stimulation isolated from showed decrease Thelper (Th)-1 IFN-γ secretion, splenic Th1/Th17 sharply increased. or NM-105 did not initiate inflammation, 100-day treatment promoted colon microinflammation initiated preneoplastic lesions also fostering growth aberrant crypt foci chemically induced carcinogenesis model. These data should be considered assessments susceptibility Th17-driven autoimmune diseases colorectal cancer humans dietary sources.