Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy

• DOI: 10.1038/srep43810
• Publication Date: 2017-03-09T10:44:18Z
• Authors: Hong-Yu Long; Li Feng; Jin Kang; Zhao-Hui Luo; Wen-Biao Xiao; Li-Li Long; Xiao-Xin Yan; Luo Zhou; Bo Xiao
• Keywords: Adult; Male; 0301 basic medicine; Adolescent; Gene Expression Profiling; Electroencephalography; DNA; DNA Methylation; Middle Aged; Magnetic Resonance Imaging; Article; Temporal Lobe; Young Adult; 03 medical and health sciences; Epilepsy, Temporal Lobe; Humans; Female; Genetic Predisposition to Disease

Abstract Mesial temporal lobe epilepsy (MTLE) is a common epileptic disorder; little known whether it associated with peripheral epigenetic changes. Here we compared blood whole genomic DNA methylation pattern in MTLE patients (n = 30) relative to controls the Human Methylation 450 K BeadChip assay, and explored genes pathways that were differentially methylated using bioinformatics profiling. The control groups showed significantly different (P < 1.03e-07) at 216 sites, 164 sites involved hyper- 52 hypo- methylation. Two 32 hypo-methylated promoters, while 87 43 corresponded coding regions. largely related predicted participate anion binding, oxidoreductant activity, growth regulation, skeletal development drug metabolism, most distinct ones included SLC34A2, CLCN6, CLCA4, CYP3A43, CYP3A4 CYP2C9. Among patients, panels of also appeared be disease duration, resistance anti-epileptics MRI alterations hippocampal sclerosis. changes observed could certain disease-related modulations warrant further translational investigations.