Differential roles of caspase-1 and caspase-11 in infection and inflammation

• DOI: 10.1038/srep45126
• Publication Date: 2017-03-27T09:28:39Z
• Authors: Si Ming Man; Rajendra Karki; Benoit Briard; Amanda Burton; Sebastien Gingras; Stephane Pelletier; Thirumala-Devi Ka...
• Keywords: Caspase 8; Caspase 2; Caspase-9

Abstract Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis converts pro-IL-1β pro-IL-18 into their biologically active forms. “ICE −/− ” or “ Casp1 mice generated using 129 embryonic stem cells carry a 129-associated inactivating passenger mutation on the caspase-11 locus, essentially making them deficient in both caspase-11. The overlapping unique functions of are difficult to unravel without additional genetic tools. Here, we caspase-1–deficient mouse ( Null ) C57BL/6 J background that expressed did not release IL-1β IL-18 response NLRC4 activators Salmonella Typhimurium flagellin, canonical non-canonical NLRP3 LPS ATP, Escherichia coli, Citrobacter rodentium transfection LPS, AIM2 Francisella novicida , cytomegalovirus DNA, infectious agents Listeria monocytogenes Aspergillus fumigatus . We further demonstrated differentially contributed defense against A. infection endotoxemia.