Higher risk of colorectal cancer in patients with newly diagnosed diabetes mellitus before the age of colorectal cancer screening initiation

• DOI: 10.1038/srep46527
• Publication Date: 2017-04-24T09:37:18Z
• Authors: Sander de Kort; Ad A. M. Masclee; Silvia Sanduleanu; Matty P. Weijenberg; Myrthe P. P. van ...; Nico J. J. Oldenhof; Joop P. W. van de...; Harm R. Haak; Maryska L. Jansse...
• Keywords: Lower risk

Abstract Type 2 diabetes mellitus (T2DM) is associated with greater risk for colorectal cancer (CRC). The age of onset T2DM decreasing worldwide. An increased CRC in young patients could be relevant the at which to initiate screening. We report on attention diagnosis. used pharmacy data (from 1998 2010) from PHARMO Database Network linked Eindhoven Cancer Registry. Multivariable time-dependent Cox regression analyses were conducted calculate hazard ratios (HR) developing comparing non-T2DM. During 2,599,925 years follow-up, 394 cases among 41,716 (mean 64.0 yr, 48% men) and 1,939 325,054 non-diabetic 51.2 46% identified. Diabetes was an both men women (HR 1.3, 95% CI 1.2–1.5), particularly first 6 months after diagnosis pronounced proximal colon. This even higher younger than 55 2.0, 1.0–3.8). a time-varying subsite-specific risk, aged <55 years.