Stereoselective oxidation and reduction by immobilized Geotrichum candidum in an organic solvent

• DOI: 10.1039/a900936a
• Publication Date: 2002-07-26T09:20:33Z
• Authors: Kaoru Nakamura; Yuko Inoue; Tomoko Matsuda; Ibuki Misawa
• Keywords: Geotrichum

Cells of the fungus, Geotrichum candidum, were immobilized on a water-absorbing polymer and used for stereoselective oxidation reduction in an organic solvent using cyclohexanone, cyclopentanol or alkan-2-ols as additive. Enantiomerically pure (R)-1-arylethanols obtained by racemic 1-arylethanols, whereas enantiomerically (S)-1-arylethanols corresponding ketones, contrast to water free cells which (R)- produced low ee.The reaction mechanism was investigated measuring partition substrates products between phase aqueous around immobilized. Deuterated compounds determine role additives.