Using graphene to protect DNA from cleavage during cellular delivery

• DOI: 10.1039/b926893f
• Publication Date: 2010-03-29T14:00:16Z
• Authors: Chun-Hua Lu; Chun-Ling Zhu; Juan Li; Jing-Jing Liu; Xi Chen; Huang-Hao Yang
• Keywords: Cell Survival; Oligonucleotides; OXIDE; 02 engineering and technology; CANCER; Carbon; MOLECULAR BEACONS; NANOPARTICLES; Humans; MESSENGER-RNAS; LIVING CELLS; 0210 nano-technology; GENE-EXPRESSION; HeLa Cells

We have proved that functionalized nanoscale graphene oxide can protect oligonucleotides from enzymatic cleavage and efficiently deliver oligonucleotides into cells.