DOTASQ as a prototype of nature-inspired G-quadruplex ligand

• DOI: 10.1039/c0cc04960c
• Publication Date: 2011-03-22T15:00:27Z
• Authors: Loic Stefan; Aurore Guédin; Samir Amrane; Nicole Smith; Franck Denat; Jean-Louis Mergny; David Monchaud
• Keywords: Models, Molecular; Binding Sites; Guanine; Macrocyclic Compounds; Fourier Analysis; Antineoplastic Agents; Ligands; 01 natural sciences; 0104 chemical sciences; G-Quadruplexes; Molecular Probes; [CHIM] Chemical Sciences; [CHIM]Chemical Sciences; Humans; Nucleic Acid Conformation; Terbium; Hydrophobic and Hydrophilic Interactions

DOTASQ (for DOTA-templated Synthetic G-quartet) is the first prototype of nature-inspired G-quadruplex ligand: its design, founded on a possible intramolecular G-quartet formation, enables it to interact with G-quadruplex DNA via an unprecedented nature-mimicking binding mode, based on the association between two G-quartets, one being native (quadruplex) and the other one artificial (ligand).