Tandem Blaise–Nenitzescu reaction: one-pot synthesis of 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones from nitriles

• DOI: 10.1039/c0ob01024c
• Publication Date: 2010-11-30T11:22:04Z
• Authors: Yu Sung Chun; Ka Yeon Ryu; Ju Hyun Kim; Hyunik Shin; Sang-gi Lee
• Keywords: Benzofuran; Tandem

In contrast to the reaction of benzoquinones with β-enaminoesters providing indoles (Nenitzescu reaction), tandem one-pot Blaise intermediate, zinc bromide complex β-enaminoesters, benzoquinone affords 5-hydroxy-α-(aminomethylene)benzofuran-2(3H)-ones in good excellent yields (tandem Blaise-Nenitzescu reaction).