An oxidative cross-dehydrogenative-coupling reaction in water using molecular oxygen as the oxidant: vanadium catalyzed indolation of tetrahydroisoquinolines

• DOI: 10.1039/c1cc15050b
• Publication Date: 2011-09-28T12:30:13Z
• Authors: Kaliyamoorthy Ala...; Guralamatta Sidda...; Kandikere Ramaiah...
• Keywords: Molecular oxygen; Aqueous medium

An aerobic oxidative cross-dehydrogenative coupling reaction between sp3 C–H and sp2 bonds is developed by employing a vanadium catalyst (10 mol%) in an aqueous medium using molecular oxygen as the oxidant. This environmentally benign strategy exhibits larger substrate scope shows high regioselectivity.