Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

• DOI: 10.1039/c1cc16647f
• Publication Date: 2011-11-30T14:00:20Z
• Authors: Jenny Z. Zhang; Ezequiel Wexselblatt; Trevor W. Hambley; Dan Gibson
• Keywords: Oxaliplatin; Magnetic Resonance Spectroscopy; Organoplatinum Compounds; Electrochemistry; Antineoplastic Agents; Prodrugs; Ascorbic Acid; Oxidation-Reduction; 01 natural sciences; 0104 chemical sciences

In contrast to the Pt(IV) derivatives of cisplatin, Pt(IV) derivatives of oxaliplatin do not show the expected correlation between the electrochemical reduction potentials and rates of reduction by ascorbate. This is probably due to the lower ability of the amine and carboxylato ligands to form a bridge with the reducing agents to facilitate electron transfer.