On-demand controlled release of docetaxel from a battery-less MEMS drug delivery device

• DOI: 10.1039/c1lc20134d
• Publication Date: 2011-06-23T11:30:30Z
• Authors: Fatemeh Nazly Pir...; John K. Jackson; Helen M. Burt; Mu Chiao
• Keywords: Dose-Response Relationship, Drug; Cell Survival; Lasers; Endothelial Cells; Membranes, Artificial; Docetaxel; 02 engineering and technology; Cell Line; 3. Good health; Magnetics; Structure-Activity Relationship; Drug Delivery Systems; Humans; Taxoids; Dimethylpolysiloxanes; 0210 nano-technology; Cell Proliferation

We report the development of a magnetically controlled MEMS device capable on-demand release defined quantities an antiproliferative drug, docetaxel (DTX). Controlled DTX with dosage suitable for treatment diabetic retinopathy has been achieved 35 days. The consists drug-loaded microreservoir (∅6 mm × ∼550 μm), sealed by elastic magnetic PDMS (polydimethylsiloxane) membrane 40 μm) laser-drilled aperture (∼100 100 μm2). By applying field, deforms, causing discharge drug solution from device. at rate 171 ± 16.7 ng per actuation interval days using 255 mT field. background leakage through was negligible 0.053 0.014 min−1. biological activity released investigated cytotoxicity assay (cell apoptosis) two cell lines, HUVEC (human umbilical vein endothelial cells) and PC3 (prostate cancer) cells. Reproducible rates have within reservoir maintains full pharmacological efficacy more than months. This is proof-of-concept targeted delivery hydrophobic drugs such as other taxane-based agents that require accurate in nanomolar concentrations.