An efficient synthesis of optically active trifluoromethyl aldimines via asymmetric biomimetic transamination

• DOI: 10.1039/c2cc37423d
• Publication Date: 2012-12-21T12:16:24Z
• Authors: Mao Liu; Jing Li; Xiao Xiao; Ying Xie; Yian Shi
• Keywords: Transamination; Aldimine

This communication describes a chiral base-catalyzed asymmetric [1,3]-proton shift of trifluoromethyl ketimines, giving wide variety aldimines containing various functional groups with up to 94% ee.