Random introduction of degradable linkages into functional vinyl polymers by radical ring-opening polymerization, tailored for soft tissue engineering

• DOI: 10.1039/c2py20034a
• Publication Date: 2012-03-20T09:35:35Z
• Authors: Jenny Undin; Teresa Illanes; Anna Finne-Wistrand; Ann-Christine Alb...
• Keywords: Vinyl acetate; Molar mass; Vinyl polymer; Polyvinyl acetate

Vinyl polymers, e.g. polyvinyl acetate and alcohol, have properties which suit tissue engineering in many perspectives. A copolymer of 2-methylene-1,3-dioxepane (MDO) with vinyl (VAc) should combine the desirable polymers degradability aliphatic polyesters. Our results detailed kinetics information show that it is possible to vary amount MDO widely copolymer. Between 1 70% was incorporated into polymer when copolymerized VAc at 60 °C using 2,2-azobisisobutyronitrile (AIBN) as an initiator. The strictly controlled by feed ratio, copolymerization resulted a high conversion, copolymers had number average molar masses. polymerization indicated ester units were added randomized manner backbone. This crucial point since distribution degradable bonds provides opportunity design degradation profile polymer. reactivity ratios for determined be rMDO = 0.93 rVAc 1.71. glass transition temperature masses increased increasing feed. We confirmed degraded rapidly alkali hydrolysis less enzymatic apparent synthesize various materials based on predetermined compositions