Ln[N(SiMe3)2]3-catalyzed cycloaddition of terminal alkynes to azides leading to 1,5-disubstituted 1,2,3-triazoles: new mechanistic features

• DOI: 10.1039/c3cc42534g
• Publication Date: 2013-04-30T13:04:49Z
• Authors: Longcheng Hong; Weijia Lin; Fangjun Zhang; Ruiting Liu; Xigeng Zhou
• Keywords: Tandem; Triple bond

The first example of rare earth metal-catalyzed cycloaddition terminal alkynes to azides resulting in the formation 1,5-disubstituted 1,2,3-triazoles is described. Preliminary studies revealed that present shows unprecedented mechanistic features involving a tandem anionic cascade cyclization and anti-addition across CC triple bond.