Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides

• DOI: 10.1039/c3cc42781a
• Publication Date: 2013-06-12T11:30:30Z
• Authors: James B. Delehanty; Juan B. Blanco-Ca...; Christopher E. Br...; Kimihiro Susumu; Michael H. Stewart; Duane E. Prasuhn; Philip E. Dawson; Igor L. Medintz
• Keywords: Bioconjugation

Modular peptides displaying both quantum dot bioconjugation motifs and specific subcellular targeting domains were constructed using a chemoselective aniline-catalyzed hydrazone coupling chemistry. Peptides ratiometrically assembled onto dots to facilitate their delivery either the plasma membrane, endosomes, cytosol or mitochondria of target cells.