Glutathione-complexed iron–sulfur clusters. Reaction intermediates and evidence for a template effect promoting assembly and stability

• DOI: 10.1039/c3cc43620a
• Publication Date: 2013-05-29T11:03:38Z
• Authors: Wenbin Qi; Jingwei Li; C. Y. Chain; G. A. Pasquevich; A. F. Pasquevich; J. A. Cowan
• Keywords: Tetramer; Iron–sulfur cluster

Assembly and stabilization of a glutathione-complexed [2Fe-2S] cluster is promoted by aggregation glutathione. The core selects the tetramer species from collection equilibrating solution aggregate species, in turn stabilized toward hydrolytic degradation. Studies glutathione derivatives, combination with mass spectrometric Mössbauer investigations provide insight on reaction intermediates during formation [2Fe-2S](GS)4(2-).