Proteins as substrates for controlled radical polymerization

• DOI: 10.1039/c3py01193c
• Publication Date: 2013-12-13T11:22:23Z
• Authors: Jaqueline D. Wallat; Katie A. Rose; Jonathan K. Pokorski
• Keywords: Surface Modification; Chain transfer; Raft; Atom-transfer radical-polymerization

This review describes fundamental contributions in the area of proteins as macroinitiators and macro-chain transfer agents (CTA) for controlled radical polymerization (CRP). The specifically highlights concept 'grafting-from' proteins, new efficient chemistry has been developed to polymerize directly from protein substrates aqueous media. As past ten years have shown, CRP proven a powerful tool functionalization proteins. considers methods used install based initiators CTAs, principle examples ATRP RAFT methods, finishes with more advanced methodologies such combination genetic modifications polymer chemistry, nanoparticles drug delivery, unnatural amino acid initiators.