Direct catalytic cross-coupling of alkenyllithium compounds

• DOI: 10.1039/c4sc03117b
• Publication Date: 2014-11-28T19:00:05Z
• Authors: Valentín Hornillos; Massimo Giannerini; Carlos Vila; Martín Fañanás-Ma...; Ben L. Feringa
• Keywords: PALLADIUM; Química organometàl·lica; ORGANOLITHIUM COMPOUNDS; 01 natural sciences; 0104 chemical sciences; CARBON-CARBON; NOBEL-PRIZE; Chemistry; ORGANIC HALIDES; Catàlisi; REAGENTS; ARYL CHLORIDES; SMALL-MOLECULE SYNTHESIS; ORTHO-METALATION; BUILDING-BLOCKS

The direct cross-coupling of alkenyllithium reagents with aryl and alkenyl halides is described. The use of a catalyst comprising Pd2(dba)3/XPhos allows for the stereoselective preparation of a wide variety of substituted alkenes in high yields under mild conditions.