Chemical synthesis of the outer core oligosaccharide of Escherichia coli R3 and immunological evaluation

• DOI: 10.1039/c5ob00177c
• Publication Date: 2015-03-03T15:01:42Z
• Authors: Wenjing Shang; Zhongying Xiao; Zaikuan Yu; Na Wei; Guohui Zhao; Qing Zhang; Mohui Wei; Xuan Wang; Peng George Wang; Tiehai Li
• Keywords: Mice, Inbred BALB C; Oligosaccharides; Chemistry Techniques, Synthetic; Escherichia coli O157; 01 natural sciences; 0104 chemical sciences; 3. Good health; Mice; Bacterial Proteins; Immunoglobulin M; Immunoglobulin G; Escherichia coli; Animals; Female; Glycoconjugates; Oxidation-Reduction

An all α-linkedEscherichia coliR3 outer core pentasaccharide was first synthesized. Its corresponding glycoconjugate can elicit specific anti-pentasaccharide antibodies within vitrobactericidal activity.