Control of the 1,2-rearrangement process by oxidosqualene cyclases during triterpene biosynthesis

• DOI: 10.1039/c5ob00714c
• Publication Date: 2015-05-26T11:31:46Z
• Authors: Shohei Takase; Yusuke Saga; Nozomi Kurihara; Shingo Naraki; Kenta Kuze; Genki Nakata; Takeshi Araki; Tetsuo Kushiro
• Keywords: 0301 basic medicine; 03 medical and health sciences; Cyclization; Mutation; Biocatalysis; Intramolecular Transferases; Triterpenes

Critical residues controlling the 1,2-rearrangement process during cycloartenol and cucurbitadienol formation in oxidosqualene cyclase were identified.