In vitro and in vivo evaluation of xanthan gum–succinic anhydride hydrogels for the ionic strength-sensitive release of antibacterial agents

• DOI: 10.1039/c5tb02046h
• Publication Date: 2016-01-29T09:36:34Z
• Authors: Bailiang Wang; Yuemei Han; Quankui Lin; Huihua Liu; Chenghui Shen; Kaihui Nan; Hao Chen
• Keywords: Succinic anhydride; Nanocarriers

In this work, we report a new approach to prepare high gel performance hydrogels which are used as ionic strength-sensitive drug release systems. Succinic anhydride (SA)-modified xanthan (XG-SA) derivatives were prepared and confirmed by Fourier transform-infrared spectroscopy proton nuclear magnetic resonance spectroscopy. Rheological measurements showed that the storage moduli (G') loss (G'') of XG-SA much higher than native XG suggesting stability hydrogels. could form stable when content dry was 1.4 wt%. Drug studies sustained gentamicin (GS) for 9 days under aqueous physiological conditions. Biofilm inhibition assay revealed XG-SA/GS sufficient inhibit biofilm formation. The Kirby-Bauer method there zone at around 8.2 mm indicating excellent bactericidal function Cytocompatibility assessment against human lens epithelial cells supported cell adhesion, proliferation migration loading dosage GS 1 mg g-1. compared in rabbit subcutaneous S. aureus infection model. yielded significantly lower degree day 7. way, promising delivery materials antibacterial applications.