Computational design of cyclic peptides for the customized oriented immobilization of globular proteins

• DOI: 10.1039/c6cp07807a
• Publication Date: 2016-12-21T09:54:43Z
• Authors: Miguel A. Soler; Alex Rodriguez; Anna Russo; Abimbola Feyisara...; Cedrix J. Dongmo ...; Cristina Cantarutti; Elena Ambrosetti; Loredana Casalis; Alessandra Corazza; Giacinto Scoles; Daniela Marasco; Alessandro Laio; Sara Fortuna
• Keywords: Physics and Astronomy (all); Physical and Theoretical Chemistry; 0303 health sciences; computationally-designed peptides; surface-bound peptide arrays; atomic force microscopy; DNA-directed immobilisation; nuclear magnetic resonance; surface plasmon resonance; atomic force microscopy; Proteins; Molecular Dynamics Simulation; Peptides, Cyclic; Chemistry Techniques, Analytical; computationally-designed peptide; nuclear magnetic resonance; Epitopes; 03 medical and health sciences; Models, Chemical; Molecular Dynamics Simulation; Peptides design, beta2-microglobulin, Chemical and spectroscopic characterization methods; surface-bound peptide array; Computer Simulation; human beta-2-microglobulin reveals; molecular-dynamics; monte-carlo; antibody fragments; organic-molecules; high-affinity; antigen; construction; lithography; recognition; surface plasmon resonance; DNA-directed immobilisation

We generate probes for the customized oriented immobilization of proteins by computational design.