The dual function of Cu-doped TiO2coatings on titanium for application in percutaneous implants

• DOI: 10.1039/c6tb00563b
• Publication Date: 2016-04-28T12:02:06Z
• Authors: Lan Zhang; Jiaqi Guo; Xiaoyan Huang; Yanni Zhang; Yong Han
• Keywords: Dual function

To endow percutaneous implants with improved skin integration and antibacterial activity, microporous TiO2 coatings doped different doses of Cu2+ (0-1.93 wt%) were directly fabricated on Ti via micro-arc oxidation (MAO). The structures investigated; the adhesion, proliferation, phenotype, differentiation extracellular collagen secretion fibroblasts, as well response Staphylococcus aureus (S. aureus), also investigated. obtained results show that all consist antase rutile, incorporation almost does not alter phase component, surface roughness topography coating. facilitates fibroblasts to switch fibrotic phenotype differentiate myofibroblasts by enhancing production intracellular specific protein contents (connective tissue growth factor (CTGF) alpha smooth muscle action (α-SMA)). Compared Ti, adhesion proliferation can be significantly enhanced coating 0.67 wt% Cu, while greatly inhibited 1.93 Cu. difference should due compromise between positive effectiveness cytotoxicity Cu2+. Cu2+-doped good properties, including contact-killing release-killing S. aureus, these properties are positively related dose in coatings.