Carbon dots as a trackable drug delivery carrier for localized cancer therapy in vivo

• DOI: 10.1039/c6tb01259k
• Publication Date: 2016-06-29T16:22:09Z
• Authors: Qinghui Zeng; Dan Shao; Xu He; Zhongyuan Ren; Wenyu Ji; Chongxin Shan; Songnan Qu; Jing Li; Li Chen; Qin Li
• Keywords: Cancer Therapy; Carbon fibers

Fluorescent carbon dots (CDs) with a size smaller than 10 nm, excellent biocompatibility, and low to no cytotoxicity are considered as rising star in nanomedicine. In this report, for the first time we demonstrate that green-emitting CDs carboxyl-rich surface can be employed trackable drug delivery agent localized cancer treatment mouse model. The conjugated drug, Doxorubicin (DOX), via non-covalent bonding, utilizing native carboxyl groups on amine moiety DOX molecules. pH difference between normal cells was successfully exploited triggering mechanism release. Our vivo study demonstrated fluorescent serve targeted system therapy, stimuli-responsive bonding nanodot carrier molecule is sufficiently stable complex biological systems. Taken together, our work provides strategy promote potential clinical application of theranostics.