Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging

• DOI: 10.1039/c7nr07035g
• Publication Date: 2017-11-22T08:03:18Z
• Authors: Tuyen Duong Thanh...; Arunkumar Pitchai...; Colin Ferrel; Ravindra Thakkar; Santosh Aryal
• Keywords: Osteosarcoma; Contrast Media; Mice, Nude; Bone Neoplasms; 02 engineering and technology; Magnetic Resonance Imaging; Magnetics; Mice; Polylactic Acid-Polyglycolic Acid Copolymer; Animals; Female; Magnetite Nanoparticles; 0210 nano-technology

Superparamagnetic iron oxide nanoparticles (SPIONs) are highly biocompatible and have a versatile synthetic technique based on coprecipitation, reduction-precipitation, hydrothermal methods, where Fe3+ Fe2+ react in aqueous solutions; both these ions present our body clear metabolic pathways; therefore, they attracted extensive research interest development the field of diagnostic imaging therapy. However, most SPION-based clinical contrast agents discontinued due to severe pain, low transverse magnetic relaxivity range 80-180 mM-1 s-1, shorter circulation half-life, lack disease specificity. Therefore, this study, we engineered bone cancer-targeted hybrid nanoconstruct (HNC) with high 625 which was significantly higher than that agents. The HNC is peripherally decorated bone-seeking agent, alendronic acid-conjugated phospholipid, exhibiting hydrodynamic size 80 nm negative surface potential, -35 mV. interior skeleton composed biodegradable poly(l-lactic-co-glycolic acid) (PLGA), 5 SPIONs confined. We successfully tuned distance between confined from 0.5 4 nm, as revealed by transmission electron microscopy (TEM) images resonance image (MRI) phantoms. This cluster confinement dramatically enhances possibly increase net local magnetization proximal inhomogeneity. In an vitro examination, 80% found bind hydroxyapatite (HAp), when characterized TEM shows painting over HAp crystal. accumulate mouse osteosarcoma tumor (K7M2 model); MRI histological examination show potential targeting for diagnosis bone.