Super-resolution localization microscopy of radiation-induced histone H2AX-phosphorylation in relation to H3K9-trimethylation in HeLa cells

• DOI: 10.1039/c7nr08145f
• Publication Date: 2018-01-24T08:34:25Z
• Authors: Michael Hausmann; Emma Wagner; Jin-Ho Lee; Gerrit Schrock; Wladimir Schaufler; Matthias Krufczik; Franziska Papenfuß; Matthias Port; Felix Bestvater; Harry Scherthan
• Keywords: Histones; 0301 basic medicine; Microscopy; 03 medical and health sciences; DNA Repair; Heterochromatin; Radiation, Ionizing; Humans; Phosphorylation; Methylation; DNA Damage; HeLa Cells

Ionizing radiation (IR)-induced damage confers functional and conformational changes to nuclear chromatin associated with DNA single and double strand breaks.