A new four-component reaction involving the Michael addition and the Gewald reaction, leading to diverse biologically active 2-aminothiophenes

• DOI: 10.1039/c7ob00707h
• Publication Date: 2017-04-11T14:53:57Z
• Authors: Joice Thomas; Sampad Jana; Mahendra Sonawane; Bert Fiey; Jan Balzarini; Sandra Liekens; Wim Dehaen
• Keywords: Moiety; Methylene; Component (thermodynamics); Michael reaction

A Gewald-four component reaction has been successfully developed for the synthesis of a series compounds containing an indole and 2-aminothiophene moiety separated by methylene spacer having anti-proliferative activity.